Detalhe da pesquisa
1.
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
J Virol
; 97(10): e0072223, 2023 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37754761
2.
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Hepatology
; 78(4): 1252-1265, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37102495
3.
Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases.
PLoS Pathog
; 17(12): e1010151, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34914795
4.
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Int J Mol Sci
; 24(22)2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003463
5.
Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase Complex.
Molecules
; 27(9)2022 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35566268
6.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33813272
7.
Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.
PLoS Pathog
; 14(2): e1006889, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425244
8.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
PLoS Pathog
; 11(6): e1004995, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26098424
9.
Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases.
Nucleic Acids Res
; 43(1): 446-60, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25520198
10.
Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases.
Antimicrob Agents Chemother
; 59(12): 7504-16, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26392512
11.
Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase.
Antimicrob Agents Chemother
; 58(7): 3636-45, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24733478
12.
Understanding the mechanisms of viral RNA synthesis: towards the discovery of new inhibitors.
Virologie (Montrouge)
; 18(3): 136-150, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33065848
13.
Meeting report: 35th International Conference on Antiviral Research in Seattle, Washington, USA - March 21-25, 2022.
Antiviral Res
; 211: 105521, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36596323
14.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
mBio
; 14(1): e0281522, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625640
15.
Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity.
J Biol Chem
; 286(3): 2067-77, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078673
16.
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
Antimicrob Agents Chemother
; 56(2): 830-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22143520
17.
Meeting report: 34th international conference on antiviral research.
Antivir Chem Chemother
; 30: 20402066221130853, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36305015
18.
Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection.
Curr Opin Virol
; 49: 36-40, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34029993
19.
Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry.
SLAS Discov
; 26(6): 766-774, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33870746
20.
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.
Antiviral Res
; 187: 105020, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515606